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The different topics developed at the Institute of Organic and Analytical Chemistry (ICOA) are directed towards the design, synthesis and analysis of small molecules likely to have biological activities.

The institute is a Mixed Research Unit (UMR 7311) of the University of Orleans and the French National Center for Scientific Research (CNRS).

ICOA is also a member of:

and is a corresponding lab of French Alternative Energies and Atomic Energy Commission (CEA) LRC M09.

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Our last 3 publications

Ferey, J. ; Da Silva, D. ; Colas, C. ; Nehmé, R. ; Lafite, P. ; Roy, V. ; Morin, Ph. ; Daniellou, R. ; Agrofoglio, L. A. ; Maunit, B.
Monitoring of successive phosphorylations of thymidine using free and immobilized human nucleoside/nucleotide kinases by Flow Injection Analysis with High-Resolution Mass Spectrometry
Anal. Chim. Acta 2019, 1049, 115-122.

Boutin, J. A. ; Bouillaud, F. ; Janda, E. ; Gascalyi, I. ; Guillaumet, G. ; Hirsch, E. C. ; Kane, D. A. ; Nepveu, F. ; Reybier, K. ; Dupuis, P. ; Bertrand, M. ; Chhour, M. ; le Diguarher, T. ; Antoine, M. ; Brebner, K. ; Da Costa, H. ; Ducrot, P. ; Giganti, A. ; Goswani, V. ; Guedouari, H. ; Michel, P. P. ; Patel, A. ; Paysant, J. ; Stojko, J. ; Viaud-Massuard, M. C. ; Ferry, G.
S29434, a quinone reductase 2 inhibitor: main biochemical and cellular characterization
Molecular Pharmacology 2019, 95, 114231.

Elie, J. ; Vercouillie, J. ; Arlicot, N. ; Lemaire, L. ; Bidault, R. ; Bodard S. ; Hosselet, C. ; Deloye, J.-B. ; Chalon, S. ; Emond, P. ; Guilloteau, D. ; Buron, F. ; Routier, S.
Design of selective COX-2 inhibitors in the (aza)indazole series. Chemistry, in vitro studies, radiochemistry and evaluations in rats of a [18F] PET tracer
J. Enzym. Inhib. Med. Chem. 2019, 34, 1-7.

Our last 2 patents

  1. Routier, S. ; Buron, F. ; Rodrigues, N. ; Fourrière-Grandclaude, G. ; Vandier, C. ; Chantome, A. ; Potier-Cartereaux, M. ; Gueguinou, M. ; Marionneau-Lambot, S.
    Ion channel inhibitor compounds for cancer treatment
  2. Patent N° Kind Date Application N° Date
    WO 2018215557 A1 29 Nov. 2018 WO 2018-EP63543 23 May 2018
    FR 3066761 A1 30 Nov. 2018 FR 2017-54564 23 May 2017

        Priority Application
                      FR 2017-54564 A 23 May 2017
        ref. chem. Abstract : 2018:2337629

  3. Yaacoub, K. ; Guillaudeux, T. ; Daniellou, R. ; Lafite, P. ; Aci-Sèche, S. ; Bonnet, P.
    Selective C-flip inhibitors as anticancer agents
  4. Patent N° Kind Date Application N° Date
    EP 3323428 A1 23 may 2018 EP 2016-306500 17 Nov 2016
    WO 2018091647 A1 24 may 2018 WO 2017-EP79575 17 Nov 2017

        Priority Application
                      EP 2016-306500 A 17 nov 2016
        ref. chem. Abstract : 2018:993556